Note that recent papers may be available through Open Access from Apollo, the University of Cambridge manuscript repository. To find papers by the Simons lab, search on "Simons BD".



    PUBLISHED, IN PRESS OR PREPRINTS

  1. Dynamic regulation of tissue fluidity controls skin repair during wound healing
    R. Sarate+, J. Hochstetter+, M. Valet+, A. Hallou, Y. Song, N. Bansaccal, M. Ligare, M. Aragona, O. Campas*, B. D. Simons* and C. Blanpain*, Cell 2024 Aug 11:S0092-8674(24)00825-0 | doi: 10.1016/j.cell.2024.07.031

  2. Mechanisms that clear mutations drive field cancerization in mammary tissue.
    M. Ciwinska, H. A. Messal, H. R. Hristova, C. Lutz, L. Bornes, T. Chalkiadakis, R. Harkes, N. S. M. Langedijk, S. J. Hutten, R. X. Menezes, J. Jonkers, S. Prekovic, Grand Challenge PRECISION consortium, B. D. Simons*, C. L. G. J. Scheele* and J. van Rheenen*, Nature 633, 198-206 (2024) | doi: 10.1038/s41586-024-07882-3
    News and Views: Breast cancer blocked by multiple natural lines of defence

  3. Dynamic regulation of tissue fluidity controls skin repair during wound healing
    R. Sarate+, J. Hochstetter+, M. Valet+, A. Hallou, Y. Song, N. Bansaccal, M. Ligare, M. Aragona, O. Campas*, B. D. Simons* and C. Blanpain*, Cell 2024 Aug 11:S0092-8674(24)00825-0 | doi: 10.1016/j.cell.2024.07.031

  4. Atypical low-frequency cortical encoding of speech identifies children with Developmental Dyslexia
    J. Araujo, B. D Simons, V. Peter, K. Mandke, M. Kalashnikova, A. Macfarlane, F. Gabrielczyk, A. M. Wilson, G. M. Di Liberto, D. K. Burnham and U. Goswami, Frontiers in Human Neuroscience 18, 1403677 (2024) | doi: 10.3389/fnhum.2024.1403677

  5. Human lymphoid-neutrophil/monocyte restriction co-ordinately activates increased proliferation despite parallel heterogeneity in transcriptional changes
    F. Wang, L. G. Campos, C. Hammond, M. Hirst, B. D. Simons and C. J. Eaves, bioRxiv 2024.02. 18.580894 doi: 10.1101/2024.02.18.580894

  6. Red2Flpe-SCON: a versatile, multicolor strategy for generating mosaic conditional knockout mice
    S.-H. Wu, S. Kim, H. Lee, J.-H. Lee, S.-Y. Park, R. Bakonyi, I. Teriyapirom, N. Hallay, S. Pilat-Carotta, H.-C. Theussl, J. Kim, J.-H. Lee, B. D. Simons, J. K. Kim, G. Colozza and B.-K. Koo, Nature Communications 15, 4963 (2024) | doi: 10.1038/s41467-024-49382-y

  7. Adult human, but not rodent, spermatogonial stem cells retain states with a foetal-like signature
    S. J. Bush, R. Nikola, S. Han, S. Suzuki, S. Yoshida, B. D. Simons and A. Goriely, Cells 13, 742 (2024) | doi: 10.3390/cells1309-742

  8. Self-tuning to the edge of bistability explains the longevity and heterogeneity of plasma cells
    B. D. Simons and O. Karin, Immunity 57, 600-611 (2024) | doi: 10.1016/j.immuni.2024.02.005
    Comment: Predicting plasma cell retention and loss over a lifetime

  9. Remediating phonological deficits in dyslexia with brain-computer interfaces
    J. Araújo, B. D. Simons, and U. Goswami, Brain-Computer Interface Research: A State-of-the-Art Summary 11, 13-19 (2024) | doi:10.1007/978-3-031-49457-4_2

  10. Understanding the cell fate and behavior of progenitors at the origin of the mouse cardiac mitral valve
    B. Fahrat, I. Bordeu, B. Jagla, S. Ibrahim; S. Stefanovic, H. Blanc, K. Loulier, B. D. Simons, E. Beaurepaire, J. Livet, and M. Pucéat, Developmental Cell 59, 1-12 (2024) | doi: 10.1101/2022.08.06.503022

  11. Heterogenous murine peribiliary glands orchestrate compartmentalized epithelial renewal
    S. Singh, Q. Lian, T. Budiman, M. M. Taketo, B. D. Simons, and V. Gupta, Developmental Cell 58, 2732-45 (2023) | pdf | doi:10.1016/j.devcel.2023.10.004

  12. A computational pipeline for spatial mechano-transcriptomics
    A. Hallou, R. He, B. D. Simons, and B. Dumitrascu, bioRxiv preprint | doi:10.1101/2023.08.03.551894

  13. Wound-healing plasticity enables clonal expansion of founder progenitor cells in colitis
    C. Liu, N. Girish, M. L. Gomez, J. K. Bernard, B. D. Simons and B. Polk, Developmental Cell 58, 2309-25 (2023) | doi: 10.1016/j.devcel.2023.08.011

  14. Cancers make their own luck: theories of cancer origins
    A. Jassim, E. P. Rahrmann, B. D. Simons, and R. J. Gilbertson, Nature Reviews Cancer 23, 710-724 (2023) | pdf | doi: 10.1038/s41568-023-00602-5

  15. flowerDifferent niches for stem cells carrying the same oncogenic driver affects pathogenesis and therapy response in myeloproliferative neoplasms
    E. Grockowiak, C. Korn, J. Rak, V. Lysenko, A. Hallou, F. M. Panvini, M. Williams, C. Fielding, Z. Fang, E. Khatib-Massalha, A. García-García, J. Li, R. A. Khorshed, S. González-Antón, E. J. Baxter, A. Kusumbe, B. S. Wilkins, A. Green, B. D. Simons, C. N. Harrison, A. R. Green, C. Lo Celso, A. P. A. Theocharides, and S. Méndez-Ferrer, Nature Cancer 4, 1193-1209 (20023) | pdf | doi: 10.1038/s43018-023-00607-x

  16. Inflationary theory of branching morphogenesis in the mouse salivary gland
    I. Bordeu+, L. Chatzeli+ and B. D. Simons, Nature Communications 14, 3422 (2023) | pdf | doi: 10.1038/s41467-023-39124-x

  17. flowerChronic in vivo imaging defines age-dependent alterations of hippocampal neurogenesis
    Y. Wu, S. Bottes, R. Fisch, C. Zehnder, J. D. Cole, G.-A. Pilz, F. Helmchen, B. D. Simons and S. Jessberger, Nature Aging 3, 380-390 (2023) | doi: 10.1038/s43587-023-00370-9
    News and Views: Seeing is believing: old clones die young

  18. Epigenetic inheritance of gene-silencing is maintained by a self-tuning mechanism based on resource competition
    O. Karin*, E. A. Miska and B. D. Simons*, Cell Systems 14, 24-40 (2023) | doi: 10.1016/j.cels.2022.12.003 | bioRxiv preprint | pdf | doi: 10.1101/2022.06.15.496123

  19. flowerCell fate specification in the developing mouse salivary gland is mediated through a cellular hierarchy controlled by Notch and Kras signaling
    L. Chatzeli*, I. Bordeu, S. Han, S. Bisetto, Z. Waheed, M. P. Alcolea and B. D. Simons*, Developmental Cell 58, 94-109 (2023) | doi: 10.1016/j.devcel.2022.12.009

  20. A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours
    A. A. Hamed, D. J. Kunz, I. El-Hamamy, Q. M. Trinh, O. D. Subedar, L. M. Richards, W. Foltz, M. C. Vladoiu, A. M. Raj, T. J. Pugh, M. D. Taylor, S. A. Teichmann, L. D. Stein*, B. D. Simons* and P. B. Dirks*, Nature Communications, 13: 4178 (2022) | pdf | doi: 10.1038/s41467-022-31408-y

  21. A cellular hierarchy in melanoma uncouples growth and metastatic phenotypes
    P. Karras, I. Bordeu, J. Pozniak, D. Pedri, E. Landeloos, N. Van Raemdonck, Y. van Herck, G. Bervoets, O. Marin-Bejar, M. Dewaele, J. Wouters, F. Bosisio, J. J. van den Oord, D. Lambrechts, A. K. Rustgi, O. Bechter, C. Blanpain, B. D. Simons, F. Rambow and J.-C. Marine, Nature 610, 190-198 (2022) | doi: 10.1038/s41586-022-05242-7
    News and Views: The hierarchy of melanoma

  22. Retrograde movements determine effective stem cell numbers in the intestine
    M. Azkanaz, B. Corominas-Murtra, S. I. J. Ellenbroek, L. Bruens, A. T. Webb, D. Laskaris, K. C. Oost, S. J. A. Lafirenze, K. Annusver, H. A. Messal, S. Iqbal, D. J. Flanagan, D. J. Huels, F. Rojas-Rodriguez, M. Vizoso, M. Kasper, O. J. Sansom, H. J. Snippert, P. Liberali, B. D. Simons*, P. Katajisto*, E. Hannezo* and J. van Rheenen*, Nature 607, 548–554 (2022) | pdf | doi: 10.1038/s41586-022-04962-0
    News and Views: Relocation sustains intestinal stem cell numbers
    F1000 recommendation

  23. Human branching cholangiocyte organoids recapitulate embryonic bile duct development
    F. Roos, G. S. van Tienderen, H. Wu, I. Bordeu, D. Vinke, M. A. Laura, K. Monfils, S. Niesten, R. M. J. M. Smits, J. Willems, O. Rosmark, G. Westergren-Thorsson, D. J. Kunz, M. de Wit, P. J. French, L. Vallier, J. N. M. I. Jzermans, R. C. Bartfai, H. Marks, B. D. Simons, M. E. van Royen, M. M. A. Verstegen and L. J. W. van der Laan, Cell Stem Cell 29, 776-794 (2022) | pdf | doi: 10.1016/j.stem.2022.04.011

  24. p57Kip2 imposes the reserve stem cell state of gastric chief cells
    J.-H. Lee, S. Kim, S. Han, J. Min, B. Caldwell, A.-D. Bamford, A. S. Batista-Rocha, H. Lee, J. Fink, S. Pilat-Carotta, J. Kim, M. Josserand, J. Y. Park, S. Lee, S.-B. Réka, Y. Ahn, Y. S. Ju, A. Philpott, B. D. Simons, D. E. Stange, E. Choi, B.-K. Koo and J. K. Kim, Cell Stem Cell 29, 826-839 (2022) | pdf | doi: 10.1016/j.stem.2022.04.001
    F1000 recommendation

  25. Transitional anal cells mediate colonic re-epithelialization in colitis
    C. Y. Liu, N. Girish, M. L. Gomez, P. E. Dubé, M. K. Washington, B. D. Simons and D. B. Polk, Gastroenterology 162, 1975-1989 (2022) | pdf | doi: 10.1053/j.gastro.2022.02.031
    Comment: Wound healing in the Colon

  26. ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation
    R. Azzarelli, A. McNally, C. Dell’Amico, M. Onorati, B. D. Simons and A. Philpott, Scientific Reports 12:2341 (2022) | doi: 10.1038/s41598-022-06248-x

  27. A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis
    T. Nakagawa, D. J. Jörg, H. Watanabe, S. Mizuno, S. Han, T. Ikeda, Y. Omatsu, K. Nishimura, M. Fujita, S. Takahashi, G. Kondoh, B. D. Simons, S. Yoshida and T. Nagasawa, Cell Reports 37, 109875 (2021) | doi: 10.1016/j.stem.2021.08.012

  28. Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration
    J. Choi, Y. J. Jang, C. Dabrowska, E. Iich, K. V. Evans, H. Hall, S. M. Janes, B. D. Simons, B.-K. Koo, J. Kim and Joo-Hyeon Lee, Nature Cell Biology 23, 953-966 (2021) | doi: 10.1038/s41556-021-00742-6
    News and Views: An inflammatory switch for stem cell plasticity

  29. Visualization of individual cell division history in complex tissues using iCOUNT
    A. Denoth-Lippuner, B. N. Jaeger, T. Liang, S. E. Chie, L. N. Royall, M. Kruse, B. D. Simons and S. Jessberger, Cell Stem Cell 28, 2020-2034 (2021) | pdf | bioRxiv 2020.08.26.266171 | pdf | doi:10.1101/2020.08.26.266171

  30. Tracing oncogene-driven remodeling of the intestinal stem cell niche
    M. K. Yum+, S. Han+, J. Fink, S.-H. Wu, C. Dabrowska, T. Trendafilova, R. Mustata, L. Chatzeli, R. Azzarelli, I. Pshenichnaya, E. Lee, F. England, J. K. Kim, D. E. Stange, A. Philpott, J.-H. Lee, B.-K. Koo* and B. D. Simons*, Nature 594, 442-447 (2021) | doi: 10.1038/s41586-021-03605-0
    News and Views: Cancer stem cells in the gut have a bad influence on neighbouring cells
    Comment: Oncogenic mutations drive intestinal cancer initiation through paracrine remodeling
    Comment: Race to the bottom: Darwinian competition in early intestinal tumorigenesis

  31. 5. Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis
    T. Lohoff, S. Ghazanfar, A. Missarova, N. Koulena, N. Pierson, J. A. Griffiths, E. S. Bardot, C.-H. L. Eng, R. C. V. Tyser, R. Argelaguet, C. Guibentif, S. Srinivas, J. Briscoe, B. D. Simons, A.-K. Hadjantonakis, B. Gottgens, W. Reik, J. Nichols, L. Cai, J. C. Marioni, Nature Biotechnology 40, 74-85 (2021) | bioRxiv 2020.11.20.391896 | pdf | doi:10.1101/2020.11.20.391896

  32. Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs
    C. Aztekin+, T. W. Hiscock+, J. B. Gurdon, J. Jullien*, J. C. Marioni* and B. D. Simons*, Development 148, dev199158 (2021) | pdf | doi:10.1242/dev.199158

  33. High proliferation and delamination during skin epidermal stratification
    M. Damen, L. Wirtz, E. Soroka, H. Khatif, C. Kukat, B. D. Simons and H. Bazzi, Nature Communications 12, 3227 (2021) | pdf | doi:10.1038/s41467-021-23386-4

  34. A biomechanical switch regulates the transition towards homeostasis in esophageal epithelium
    J. McGinn, A. Hallou, S. Han, K. Krizic, S. Ulyanchenko, R. Iglesias-Bartolome, F. J. England, C. Verstreken, K. J. Chalut, K. B. Jensen, B. D. Simons and M. P. Alcolea, Nature Cell Biology 23, 511-525 (2021) | pdf | bioRxiv 2021.02.03.428820 | pdf | doi:10.1038/s41556-021-00679-w

  35. Early stem cell aging in the mature brain
    A. Ibrayeva, M. Bay, E. Pu, D. J. Jörg, L. Peng, H. Jun, N. Zhang, D. Aaron, C. Lin, G. Resler, A. Hidalgo, M.-H. Jang, B. D. Simons and M. A. Bonaguidi, Cell Stem Cell 28, 955-966 (2021) | pdf | bioRxiv 654608 | pdf | doi:10.1016/j.stem.2021.03.018
    Comment: The future belongs to those who prepare for it today

  36. Transient suppression of transplanted spermatogonial stem cell differentiation restores fertility in mice
    Y. Nakamura, D. J. Jörg, Y. Kon, B. D. Simons* and S. Yoshida*, Cell Stem Cell 28, 955-966.e7 (2021) | pdf | doi:10.1016/j.stem.2021.03.016

  37. Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids
    R. Azzarelli, M. Ori, A. Philpott and B. D. Simons, Biology Open 10, bio056416 (2021) | pdf | doi: 10.1242/bio.056416 | PMCID: PMC7928227

  38. Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation
    U. Dobramysl, I. K. Jarsch, Y. Inoue, H. Shimo, B. Richier, J. R. Gadsby, J. Mason, A. Szałapak, P. S. Ioannou, G. P. Correia, A. Walrant, R. Butler, E. Hannezo, B. D. Simons and J. L. Gallop, J. Cell Biol. 220:e202003052 (2021) | pdf | doi: 10.1083/jcb.202003052

  39. Distinct progenitor behavior underlying neocortical gliogenesis related to tumorigenesis
    Z. Shen, Y. Lin, J. Yang, D. J. Jörg, Y. Peng, X. Zhang, L. Hernandez, J. Ma, B. D. Simons* and S. -H. Shi*, Cell Reports 34, 108853 (2021) | pdf | bioRxiv 2020.10.13.338459 | doi:10.1016/j.celrep.2021.108853

  40. Stem Cell Populations as Self-Renewing Many-Particle Systems
    D. J. Jörg, Y. Kitadate, S. Yoshida, and B. D. Simons
    Annual Review of Condensed Matter Physics 12 1350153 (2021) | doi:10.1146/annurev-conmatphys-041720-125707
    Early preprint version: arXiv:1901.03903 | pdf

  41. Behavior and lineage progression of neural progenitors in the mammalian cortex
    Y. Lin, J. Yang, Z. Shen, J. Ma, B. D. Simons and S.-H. Shi, Current Opinion in Neurobiology 66, 144-157 (2021) | pdf | doi:10.1016/j.conb.2020.10.017

  42. Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging
    S. Bottes, B. N. Jaeger, G. Pilz, D. J. Jörg, J. D. Cole, M. Kruse, L. Harris, V. I. Korobeynyk, I. Mallona, F. Helmchen, F. Guillemot, B. D. Simons and S. Jessberger, Nature Neuroscience 24, 225-233 (2021) | pdf | doi:10.1038/s41593-020-00759-4
    F1000 recommendation

  43. Tracing the cellular basis of islet specification in mouse pancreas
    M. Sznurkowska+, E. Hannezo+, R. Azzarelli, L. Chatzeli, T. Ikeda, S. Yoshida, A. Philpott* and B. D. Simons*, Nature Communications 11, 5037 (2020) | pdf | doi:10.1038/s41467-020-18837 | PMCID: PMC7541446

  44. Mechanisms of stretch-mediated skin expansion at single-cell resolution
    M. Aragona, S. Dekoninck, M. Malfait, Y. Song, A. Sifrim, J. Van Herck, S. Gargouri, G. Lapouge, B. Swedlund, C. Dubois, P. Baatsen, K. Vints, F. Tissir, T. Voet, B. D. Simons* and C. Blanpain*, Nature 584, 268-273 (2020) | pdf | doi:10.1038/s41586-020-2555-7 | PMCID: PMC7116042
    News and Views: Stretch exercises for stem cells expand the skin

  45. Stem cell lineage survival as a noisy competition for niche access
    B. Corominas-Murtraa, C. L. G. J. Scheele, K. Kishi, S. Ellenbroek, B. D. Simons, J. van Rheenen and E. Hannezo, Proceedings of the National Academy Sciences (USA) 117, 16969-16975 (2020) | pdf | doi:10.1073/pnas.1921205117 | PMCID: PMC7382312

  46. flowerDefining the design principles of skin epidermis postnatal growth
    S. Dekoninck, E. Hannezo, A. Sifrim, Y. A. Miroshnikova, M. Aragona, M. Malfait, S. Gargouri, C. de Neunheuser, C. Dubois, T. Voet, S. A. Wickström, B. D. Simons and C. Blanpain
    Cell 181, 604-620.e22 (2020) | doi: 10.1016/j.cell.2020.03.015 | PMCID: PMC7198979

  47. Lineage hierarchies and stochasticity ensure the long-term maintenance of adult neural stem cells
    E. Than-Trong, B. Kiani, N. Dray, S. Ortica, B. D. Simons, S. Rulands, A. Alunni and L. Bally-Cuif
    Science Advances 6, eaaz5424 (2020) | bioRxiv 663922 | doi:10.1126/sciadv.aaz5424

  48. Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes
    D. J. McCarthy, R. Rostom, Y. Huang, D. J. Kunz, P. Danecek, M. J. Bonder, T. Hagai, R. Lyu, HipSci Consortium, W. Wang, D. J. Gaffney, B. D. Simons, O. Stegle and S. A. Teichmann
    Nature Methods 17, 414-421 (2020) | bioRxiv 413047 | doi:10.1101/413047

  49. Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids
    N. Georgakopoulos, N. Prior, B. Angres, G. Mastrogiovanni, A. Cagan, D. Harrison, C. J. Hindley, R. Arnes-Benito, S. S. Liau, A. Curd, N. Ivory, B. D. Simons, I. Martincorena, H. Wurst, K. Saeb-Parsy and M. Huch
    BMC Developmental Biology volume 20, 4 (2020) | pdf | doi: 10.1186/s12861-020-0209-5 | PMCID: PMC7043048

  50. Tracing the dynamics of stem cell fate
    L. Chatzeli and B. D. Simons
    Cold Spring Harbor Perspectives in Biology, a036202 (2020) | pdf | doi: 10.1101/cshperspect.a036202

  51. Mutations in thyroid hormone receptor alpha1 cause premature neurogenesis and progenitor cell depletion in human cortical development
    T. G. Krieger, C. M. Moran, A. Frangini, W. E. Visser, E. Schoenmakers, F. Muntoni, C. Clark, D. Gadian, W. K. Chong, A. Kuczynski, M. Dattani, G. Lyons, A. Efthymiadou, F. Varga-Khadem, B. D. Simons, K. Chatterjee and F. J. Livesey
    Proceedings of the National Academy of Sciences USA 116, 22754-22763 (2019) | pdf | doi:10.1101/529677 | PMCID: PMC6842615

  52. Defining the identity and dynamics of adult gastric isthmus stem cells
    S. Han+, J. Fink+, D. J. Jörg, E. Lee, M. K. Yum, L. Chatzeli, S. R. Merker, M. Josserand, T. Trendafilova, A. Andersson- Rolf, C. Dabrowska, H. Kim, R. Naumann, J.-H. Lee, N. Sasaki, R. L. Mort, I. J. Jackson, O. Basak, H. Clevers, D. E. Stange, A. Philpott, J. K. Kim*, B. D. Simons* and B.-K. Koo*
    Cell Stem Cell 25, 342-356 (2019) | pdf | doi:10.1016/j.stem.2019.07.008 | PMCID: PMC6739486
    Press release: Profiling the stem cell characters in the story of stomach lining renewal

  53. Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states
    M. S. Andersen, E. Hannezo, S. Ulyanchenko, Y. Antoku, K. Boonekamp, S. Sendrup, D. Clement, B. D. Simons* and K. B. Jensen*
    Nature Cell Biology 21, 924-932 (2019) | pdf | doi:10.1038/s41556-019-0362-x | PMCID: PMC6978139

  54. Identification of a regeneration organizing cell defining the specialized wound epidermis of the Xenopus tail
    C. Aztekin+, T.W. Hiscock+, J.C. Marioni, J. B. Gurdon, B. D. Simons* and J. Jullien*
    Science 364, 653-658 (2019) | pdf | doi:10.1126/science.aav9996 | PMCID: PMC6986927
    Perspective: The cells of regeneration
    Perspective: Development: How Tadpoles ROC Tail Regeneration
    Editorial: A tale of tadpole regeneration
    Press release: Scientists find new type of cell that helps tadpoles’ tails regenerate
    Times newspaper: Tadpole cells spawn hope of human regneration
    Le Monde: Comment les têtards font repousser leur queue
    F1000 recommendation

  55. Tracing the origin of adult mouse intestinal stem cells
    J. Guiu, E. Hannezo, S. Yui, S. Ulyachanka, A. Jørgensen, S. Perlman, L. Lundvall, L. S. Mamsen, A. Larsen, R. H. Olesen, C. Y. Andersen, L. L. Thuesen, K. J. Hare, B. D. Simons and K. B. Jensen
    Nature 570, 107-111 (2019) | pdf | doi:10.1038/s41586-019-1212-5 | PMCID: PMC6986928
    European Scientist: All immature cells of the gut can become intestinal stem cells

  56. Lgr5+ stem/progenitor cells reside at the apex of the embryonic hepatoblast pool
    N. Prior, C. J. Hindley, F. Rost, E. Melendez, W. W. Y. Lau, B. Göttgens, S. Rulands, B. D. Simons and M. Huch
    Development 146 dev174557 (2019) | pdf | doi:10.1016/j.celrep.2019.05.035 | PMCID: PMC6602348

  57. Single cell transcriptome analyses reveal novel targets modulating cardiac neovascularisation by resident endothelial cells following myocardial infarction
    Z. Li, E. G. Solomonidis, M. Meloni, R. S. Taylor, R. Duffin, R. Dobie, M. S. Magalhaes, B. E. P. Henderson, P. A. Louwe, G. D’Amico, K. M. Hodivala-Dilke, A. M. Shah, N. L. Mills, B. D. Simons, G. A. Gray, N. C. Henderson, A. H. Baker, M. Brittan
    European Heart Journal 40, 2507-2520 (2019) | pdf | doi:10.1093/eurheartj/ehz305 | PMCID: PMC6685329
    Commentary: Clonal and diverse: revisiting cardiac endothelial cells after myocardial infarction

  58. Multiscale dynamics of branching morphogenesis
    E. Hannezo and B. D. Simons
    Current Opinion in Cell Biology 60, 99-105 (2019) | pdf | doi:10.1016/j.ceb.2019.04.008

  59. Intratumoral genetic and functional heterogeneity in pediatric glioblastoma
    M. Hoffman, A. H. Gillmor, D. J. Kunz, M. Johnston, A. Nikolic, K. Narta, M. Zarrei, J. King, K. Ellestad, N. H. Dang, F. M. G. Cavalli, M. M. Kushida, F. J. Coutinho, B. Luu, Y. Ma, A. J. Mungall, R. Moore, M. A, Marra, M. D. Taylor, T. J. Pugh, P. B. Dirks, S. Scherer, D. L. Senger, B. D. Simons, J. A. Chan, A. S. Morrissy and M. Gallo
    Cancer Research 79, 2111-2123 (2019) | pdf | doi:10.1158/0008-5472.CAN-18-3441 | PMCID: PMC7282886

  60. Crypt fusion as a homeostatic mechanism in the human colon
    A. -M. Baker, C. Gabbutt, M. J. Williams, B. Cereser, N. Jawad, M. Rodriguez-Justo, M. Jansen, C. P. Barnes, B. D. Simons, S. A. C. McDonald, T. A. Graham and N. A. Wright
    Gut 68, 1986-1993 (2019) | pdf | doi:10.1136/gutjnl-2018-317540 | PMCID: PMC6839731

  61. The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism
    D. J. Jörg, E. E. Caygill, A. E. Hakes, E. G. Contreras, A. H. Brand and B. D. Simons
    eLife 8, e40919 (2019) | doi:10.7554/eLife.40919 | PMCID: PMC6386523

  62. A single-cell molecular map of mouse gastrulation and early organogenesis
    B. Pijuan-Sala, J. Griffiths, C. Guibentif, T. Hiscock, W. Jawaid, F. Calero-Nieto, C. Mulas, X. Ibarra-Soria, R. Tyser, S. Srinivas, B. D. Simons, J. Nichols, J. Marioni, D. Ho, W. Reik and B. Göttgens
    Nature 566, 490-495 (2019) | pdf | doi:10.1038/s41586-019-0933-9 | PMCID: PMC6522369

  63. Competition for mitogens regulates spermatogenic stem cell homeostasis in an open niche
    Y. Kitadate, D. J. Jörg, M. Tokue, A. Maruyama, R. Ichikawa, S. Tsuchiya, E. Segi-Nishida, T. Nakagawa, A Uchida, C. Kimura-Yoshida, S. Mizuno, F. Sugiyama, T. Azami, M. Ema, C. Noda, S. Kobayashi, I. Matsuo, Y. Kanai, T. Nagasawa, Y. Sugimoto, S. Takahashi, B. D. Simons* and S. Yoshida*
    Cell Stem Cell 24, 79-92 (2019) | pdf | doi:10.1016/j.stem.2018.11.013 | PMCID: PMC6327111
    Preview: Competition for Food Drives Stem Cell Fate in Facultative Niches
    Press release: How sperm stem cells maintain their number

  64. Extreme value statistics of mutation accumulation in renewing cell populations
    P. Greulich and B. D. Simons
    Physical Review E (Rapid Communications) 98, 050401(R) (2018) | pdf | doi:10.1103/PhysRevE.98.050401
    Editor's suggestion

  65. Statistical theory of branching morphogenesis
    E. Hannezo and B. D. Simons
    Development Growth and Differentiation 60, 512-521 (2018) | pdf | doi:10.1111/dgd.12570 | PMCID: PMC6334508

  66. Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells
    R. Azzarelli, S. Rulands, S. Nestorowa, J. Davies, S. Campinoti, S. Gillotin, P. Bonfanti, B. Göttgens, M. Huch, B. D. Simons and A. Philpott
    Scientific Reports 8, 15374 (2018) | pdf | doi:10.1038/s41598-018-33838-5

  67. Metabolic regulation of pluripotency and germ cell fate through α-ketoglutarate
    J. Tischler, W. Gruhn, J. Reid, E. Allgeyer, F. Buettner, C. Marr, F. J. Theis, B. D. Simons, L. Wernisch and M. A. Surani
    EMBO Journal, e99518 (2018) | pdf | doi:10.15252/embj.201899518 | PMCID: PMC6315289

  68. Defining lineage potential and fate behavior of precursors during pancreas development
    M. K. Sznurkowska, E. Hannezo, S. Rulands, S. Nestorowa, C. J. Hindley, R. Azzarelli, J. Nichols, B. Göttgens, M. Huch, A. Philpott* and B. D. Simons*
    Developmental Cell 46, 360-375 (2018) | pdf | doi:10.1016/j.devcel.2018.06.028 | PMCID: PMC6085117

  69. Genome-scale oscillations in DNA methylation during exit from pluripotency
    H. J. Lee*, S. Rulands*, S. J. Clarke, C. Angermueller, S. A. Smallwood, F. Krueger, H. Mohammed, W. Dean, J. Nichols, P. Rugg-Gunn, G. Kelsey, O. Stegle, B. D. Simons* and W. Reik*
    Cell Systems 7, 63-76 (2018) | bioRxiv 338822 | pdf | doi:10.1016/j.cels.2018.06.012 | PMCID: PMC6066359
    See also the complementary study: Dynamics and spatial genomics of the nascent transcriptome in single mESCs by intron seqFISH

  70. Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland
    A. M. Lilja, V. Rodilla, M. Huyghe, E. Hannezo, O. Renaud, O. Leroy, B. D. Simons and S. Fre
    Nature Cell Biology 20, 677-687 (2018) | doi:10.1038/s41556-018-0108-1 | PMCID: PMC6984964
    Commentary: Mammary lineage restriction in development

  71. The developmental origin of brain tumours: a cellular and molecular framework
    R. Azzarelli, B. D. Simons and A. Philpott
    Development 145: dev162693 (2018) | pdf | doi:10.1242/dev.162693 | PMCID: PMC6001369

  72. Predominant asymmetrical stem cell fate outcome limits the rate of niche succession in human colonic crypts
    C. Stamp, A. Zupanic, A. Sachdeva, D. P. Shanley, J. C. Mathers, T. B. L. Kirkwood, R. Heer, B. D. Simons, D. M. Turnbull and L. C. Greaves
    EBio Medicine 31, 166-173 (2018) | pdf | doi:10.1016/j.ebiom.2018.04.017 | PMCID: PMC6013780
    See discussion in Intestinal Stem Cell Dynamics: A Story of Mice and Humans

  73. Integrin α2 marks a niche of trophoblast progenitor cells in first trimester human placenta
    C. Q. E. Lee, M. Turco, L. Gardner, B. D. Simons, M. Hemberger and A. Moffett
    Development 145: dev162305 (2018) | | doi:10.1242/dev.162305 | PMCID: PMC6124543

  74. flowerUniversality of clone dynamics during tissue development
    S. Rulands*, F. Lescroart, S. Chabab, C. J. Hindley, N. Prior, M. K. Sznurkowska, M. Huch, A. Philpott, C. Blanpain and B. D. Simons*
    Nature Physics 14, 469-474 (2018) | pdf | doi:10.1038/s41567-018-0055-6 | PMCID: PMC5935228
    Commentary: Sensing and making sense of clonal fragmentation in developing tissues

  75. Live imaging of neurogenesis in the adult mouse hippocampus
    G. -A. Pilz, S. Bottes, M. Betizeau, D. J. Jörg, S. Carta, B. D. Simons, F. Helmchen and S. Jessberger
    Science 359, 658-662 (2018) | pdf | doi:10.1126/science.aao5056 | PMCID: PMC6986926
    Commentary: Revising concepts about adult stem cells
    F1000 recommendation

  76. Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation
    X. Ibarra-Soria, W. Jawaid, B. Pijuan-Sala, V. Ladopoulos, A. Scialdone, D. J. Jörg, R. V. Tyser, F. J. Calero-Nieto, C. Mulas, J. Nichols, L. Vallier, S. Srivnivas, B. D. Simons, B. Göttgens and J. C. Marioni
    Nature Cell Biology 20, 127-134 (2018) | doi:10.1038/s41556-017-0013-z | PMCID: PMC5787369

  77. Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
    O. Basak, T. Krieger, M. Muraro, K. Wiebrands, D. Stange, J. Aldeguer, N. Rivron, M. van de Wetering, J. Es, A. van Oudenaarden, B. D. Simons* and H. Clevers*
    Proceedings of the National Academy Sciences (USA) 115, E610-E619 (2018) | pdf | doi: 10.1073/pnas.1715911114 | PMCID: PMC5789932
    F1000 recommendation

  78. Muscle Stem Cells Exhibit Distinct Clonal Dynamics in Response to Tissue Repair and Homeostatic Aging
    M. T. Tierney, M. J. Stec, S. Rulands, B. D. Simons and A. Sacco
    Cell Stem Cell 22, 119-127 (2018) | pdf | doi:10.1016/j.stem.2017.11.009 | PMCID: PMC5945549
    F1000 recommendation

  79. A unifying theory of branching morphogenesis
    E. Hannezo*, C. L. G. J. Scheele, M. Moad, N. Drogo, R. Heer, R. V. Sampogna, J. van Rheenen* and B. D. Simons*
    Cell 171, 242-255 (2017) | pdf | doi:10.1016/j.cell.2017.08.026 | PMCID: PMC5610190
    Commentary: Scientists reveal the "beautiful" simplicity underlying branching patterns in tissue
    Naked Scientist podcast: How do tissues grow?
    Perspective: Plumbing 101: Building the body’s tubes and branches

  80. Cell fate mapping of human glioblastoma reveals an invariant stem cell hierarchy pre- and post-treatment
    X. Lan, D. J. Jörg, L. V. Nguyen, R. J. Vanner, D. Pellacani, L. Lee, N. I. Park, M. Kushida, H. Whetstone, A. Carles, M. Moksa, R. Head, F. J. Coutinho, H. J. Selvadurai, S. Dolma, P. Prinos, M. Bernstein, C. H. Arrowsmith, M. Gallo, M. Hirst, C. J. Eaves, B. D. Simons* and P. B. Dirks*
    Nature 549, 227-232 (2017) | pdf | doi:10.1038/nature23666 | PMCID: PMC5608080
    Commentary: Tracing Cell Dynamics during Cancer Growth
    Commentary: A function-first look at tumor heterogeneity
    Commentary: Stem Cells - masters of their fates
    Commentary: Glioblastoma Stem Cell Clonal Dynamics Drive Intratumor Heterogeneity
    Press reports: Toronto Star | CTV News
    F1000 recommendation

  81. Emergence and universality in the regulation of stem cell fate
    S. Rulands and B. D. Simons
    Current Opinion in Systems Biology 5, 57-62 (2017) | pdf | doi:10.1016/j.coisb.2017.08.001

  82. Multipotent basal stem cells, maintained in localized proximal niches, support directed long-ranging epithelial flows in the adult human prostate
    M. Moad, E. Hannezo, S. J. Buczacki, L. Wilson, A. El Sherif, D. Sims, R. Pickard, N. A. Wright, S. C. Williamson, D. M. Turnbull, R. W. Taylor, L. Greaves, C. N. Robson, B. D. Simons* and R. Heer*
    Cell Reports 20, 1609–1622 (2017) | pdf | doi:10.1016/j.celrep.2017.07.061 | PMCID: PMC5565638
    F1000 recommendation

  83. Multi-site Neurogenin3 phosphorylation controls pancreatic endocrine differentiation
    R. Azzarelli, C. Hurley, M. K. Sznurkowska, S. Rulands, L. Hardwick, I Gamper, F. Ali, L. McCracken, C. Hindley, F. McDuff, S. Nestorowa, R. Kemp, K. Jones, B. Göttgens, M. Huch, G. Evan, B. D. Simons, D. J. Winton and A. Philpott
    Developmental Cell 41, 274-286 (2017) | pdf | doi:10.1016/j.devcel.2017.04.004 | PMCID: PMC5425251
    Commentary: Beta Cell Renewal versus Differentiation: Slow and Steady Wins the Race

  84. Long-term organoid cultures of human endometrium in chemically-defined medium respond to reproductive hormones
    M. Y. Turco, L. Gardner, J. Hughes, T. Cindrova-Davies, M. J. Gomez, L. Farrell, M. Hollinshead, S. G. E. Marsh, J. J. Brosens, H. O. Critchley, B. D. Simons, M. Hemberger, B.-K. Koo, A. Moffett and G. Burton
    Nature Cell Biology 19, 568-577 (2017) | pdf | doi:10.1038/ncb3516 | PMCID: PMC5410172
    Commentary: Miniature "womb lining" grown in lab could reveal secrets of menstrual cycle and early pregnancy

  85. Identity and dynamics of mammary stem cells during branching morphogenesis
    C. L. G. J. Scheele, E. Hannezo, A. Zomer, N. S. M. Langedijk, B. D. Simons* and J. van Rheenen*
    Nature 542, 313-317 (2017) | pdf | doi:10.1038/nature21046 | PMCID: PMC6097610
    Preview: Un(MaSC)ing Stem Cell Dynamics in Mammary Branching Morphogenesis

  86. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis
    M. Aragona, S. Dekoninck, S. Rulands, S. Lenglez, G. Mascré, B. D. Simons and C. Blanpain
    Nature Communications 8, 14684 (2017) | pdf | doi:10.1038/ncomms14684 | PMCID: PMC5339881

  87. flowerExtensive Proliferation of a Subset of Differentiated, Yet Plastic, Medial Vascular Smooth Muscle Cells Contribute to Neointimal Formation in Mouse Injury and Atherosclerosis Models
    J. Chappell, J. L. Harman, V. M. Narasimhan, H. Yu, K. Foote, B. D. Simons, M. R. Bennett and H. F. Jorgensen
    Circulation Research 119, 1313-1323 (2016) | doi:10.1161/CIRCRESAHA.116.309799 | PMCID: PMC5149073
    F1000 Recommendation

  88. A single dividing cell population with imbalanced fate drives oesophageal tumour growth
    J. Frede, P. Greulich, T. Nagy, B. D. Simons and P. H. Jones
    Nature Cell Biology 18, 967-78 (2016) | doi:10.1038/ncb3400 | PMCID: PMC5870829

  89. Tracing cellular dynamics in tissue development, maintenance and disease
    S. Rulands and B. D. Simons
    Current Opinion in Cell Biology 43, 38-45 (2016) | doi:10.1016/j.ceb.2016.07.001

  90. Defining the clonal dynamics leading to mouse skin tumour initiation
    A. Sanchez-Danes, E. Hannezo, J.-C. Larsimont, M. Liagre, K. K. Youssef, B. D. Simons* and C. Blanpain*
    Nature 536, 298-303 (2016) | doi:10.1038/nature19069 | PMCID: PMC5068560
    Commentary: Where did it all go wrong?

  91. Dynamic heterogeneity as a strategy of stem cell self-renewal
    P. Greulich and B. D. Simons
    Proceedings of the National Academy of Sciences (USA) 113, 7509-7514 (2016) | doi:10.1073/pnas.1602779113 | PMCID: PMC4941513

  92. Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing
    E. Rognoni, C. Gomez, A. O. Pisco, E. L. Rawlins, B. D. Simons, F. M. Watt, R. R. Driskell
    Development 143, 2522-2535 (2016) | doi:10.1242/dev.131797 | PMCID: PMC4958333
    F1000 recommendation

  93. Quantitative lineage tracing strategies to resolve multipotency in tissue specific stem cells
    A. Wuidart, M. Ousset, S. Rulands, B. D. Simons, A. Van Keymeulen and C. Blanpain
    Genes and Development 30, 1261-1277 (2016) | pdf | doi:10.1101/gad.280057.116 | PMCID: PMC4911926
    F1000 recommendation

  94. 2D and 3D stem cell models of primate cortical development identify species-specific differences in progenitor behavior contributing to brain size
    T. Otani, M. C. Matchetto, F. H. Gage, B. D. Simons and F. J. Livesey
    Cell Stem Cell 18, 467-480 (2016) | doi:10.1016/j.stem.2016.03.003 | PMCID: PMC4826446
    Preview: Stem cells expand insights into human brain evolution
    F1000 Recommendation

  95. The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue
    Y. Wan, A. D. Almeida, S. Rulands, N. Chalour, L. Muresan, Y. Wu, B. D. Simons, J. He and W. Harris
    Development 143, 1099-1107 (2016) | doi:10.1242/dev.133314 | PMCID: PMC4852496

  96. Reply to Martincorena et al.: Evidence for constrained positive selection of cancer mutations in normal skin is lacking
    B. D. Simons
    Proceedings of the National Academy of Sciences (USA) 113, E1130-31 (2016) | doi:10.1073/pnas.1601045113 | PMCID: PMC4780657

  97. Deep sequencing as a probe of stem cell fate and preneoplasia in human epidermis
    B. D. Simons
    Proceedings of the National Academy of Sciences (USA) 113, 128-133 (2016) | doi:10.1073/pnas.1516123113 | PMCID: PMC4711853

  98. flowerUncovering the number and clonal dynamics of Mesp1 progenitors during heart morphogenesis
    S. Chabab, F. Lescroart, S. Rulands, N. Mathiah, B. D. Simons* and C. Blanpain*
    Cell Reports 14, 1-10 (2016) | doi:10.1016/j.celrep.2015.12.013 | PMCID: PMC4709258

  99. Human keratinocytes have two interconvertible modes of proliferation
    A. Roshan, K. Murai, J. Fowler, B. D. Simons, V. Nikolaidou-Neokosmidou and P. H. Jones
    Nature Cell Biology 18, 145-156 (2015) | doi:10.1038/ncb3282 | PMCID: PMC4872834

  100. Dynamics of Lgr6+ progenitor cells in the hair follicle, sebaceous gland and interfollicular epidermis
    A. Füllgrabe, S. Joost, A. Are, T. Jacob, U. Sivan, A. Haegebarth, S. Linnarsson, B. D. Simons, H. Clevers, R. Toftgård and M. Kasper
    Stem Cell Reports 5, 843-855 (2015) | doi:10.1016/j.stemcr.2015.09.013 | PMCID: PMC4649262

  101. Stem and progenitor cell division kinetics during postnatal mouse mammary gland development
    R. R. Giraddi, M. Shehata, M. Gallardo, M. A. Blasco, B. D. Simons and J. Stingl
    Nature Communications 6, 8487 (2015) | doi:10.1038/comms9487 | PMCID: PMC4632194

  102. The independent probabilistic firing of transcription factors: A paradigm for clonal variability in the zebrafish retina
    H. Boije, S. Rulands, S. Dudczig, B. D. Simons and W. A. Harris
    Developmental Cell 34, 532-543 (2015) | doi:10.1016/j.devcel.2015.08.011 | PMCID: PMC4572358

  103. Cell competition modifies adult stem cell and tissue population dynamics in a JAK-STAT dependent manner
    G. Kolahgar, S. J. E. Suijkerbuijk, E. Poirier, S. Mansour, B. D. Simons and E. Piddini
    Developmental Cell 34, 297-309 (2015) | doi:10.1016/j.devcel.2015.06.010 | PMCID: PMC4537514
    F1000 Recommendation

  104. Clonal dynamics reveal two distinct populations of basal cells in slow-turnover airway epithelium
    J. K. Watson, S. Rulands, A. C. Wilkinson, A. Wuidart, M. Ousset, A. van Keymeulen, B. Gottgens, C. Blanpain, B. D. Simons and E. L. Rawlins
    Cell Reports 12, 90-101 (2015) | doi:10.1016/j.celrep.2015.06.011 | PMCID: PMC4518462

  105. Dynamic stem cell heterogeneity
    T. G. Krieger and B. D. Simons
    Development 142, 1396-1406 (2015) | doi:10.1242/dev.101063

  106. Deterministic progenitor behavior and unitary neuron production in the neocortex
    P. Gao, M. P. Postiglione, T. G. Krieger, L. Hernandez, C. Wang, Z. Han, C. Streicher, E. Papusheva, R. Insolera, K. Chugh, O. Kodish, K. Huang, B. D. Simons*, L. Luo*, S. Hippenmeyer* and Song-Hai Shi*
    Cell 159, 775-788 (2014) | doi:10.1016/j.cell.2014.10.027 | PMCID: PMC4225456
    F1000 recommendation

  107. Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development
    F. Lescroart, S. Chabab, X. Lin, S. Rulands, C. Paulissen, A. Rodolosse, H. Auer, Y. Achouri, C. Dubois, A. Bondue, B. D. Simons and C. Blanpain
    Nature Cell Biology 16, 829-840 (2014) | doi:10.1038/ncb3024 | PMCID: PMC6984965

  108. Exclusive multipotency and preferential asymmetric divisions in post-embryonic neural stem cells of the fish retina
    L. Centanin, J. J. Ander, B. Hoeckendorf, K. Lust, T. Kellner, I. Kraemer, C. Urbany, E. Hasel, W. A. Harris, B. D. Simons and J. Wittbrodt
    Development 141, 3472-3482 (2014) | pdf | doi:10.1242/dev.109892 | PMCID: PMC4197724

  109. Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo
    M. Amoyel, B. D. Simons and E. A. Bach
    EMBO Journal 33, 2295-2313 (2014) | pdf | doi:10.15252/embj.201387500 | PMCID: PMC4253521
    Commentary: Stem cell competition: how speeding mutants beat the rest

  110. Quantification of the clonal evolution of human stem cells and crypts in normal, preneoplastic and neoplastic colon
    A.-M. Baker, B. Cereser, S. Melton, A. G. Fletcher, M. Rodriguez-Justo, P. J. Tadrous, G. Elia, S. A. C. McDonald, N. A. Wright, B. D. Simons*, M. Jansen* and T. A. Graham*
    Cell Reports 8, 940-947 (2014) | pdf | doi:10.1016/j.celrep.2014.07.019 | PMCID: PMC4471679
    Commentary: Stem cell competition: how speeding mutants beat the rest
    Commentary: Measuring stem cell dynamics in the human colon – where there's a wiggle, there's a way

  111. Differentiation imbalance in single esophageal progenitor cells causes clonal immortalization and field change
    M. P. Alcolea, P. Greulich, A. Wabik, J. Frede, B. D. Simons and P. H. Jones
    Nature Cell Biology 16, 615-622 (2014) | pdf | doi:10.1038/ncb2963 | PMCID: PMC4085550

  112. Mouse spermatogenic stem cells continually interconvert between equipotent singly isolated and syncytial states
    K. Hara, T. Nakagawa, H. Enomoto, M. Suzuki, M. Yamamoto, B. D. Simons* and S. Yoshida*
    Cell Stem Cell 14, 658-672 (2014) | pdf | doi:10.1016/j.stem.2014.01.019 | PMCID: PMC4010676
    Highlight: Sperm Spawned by Shifty, Shape-Shifting Stem Cells

  113. The human squamous oesophagus has widespread capacity for clonal expansion from cells at diverse stages of differentiation
    M. Barbera, M. di Pietro, E. Walker, C. Brierley, S. Macrae, B. D. Simons, P. H. Jones, J. Stingl and R. C. Fitzgerald
    Gut 64, 11-19 (2015) | pdf | doi:10.1136/gutjnl-2013-306171 | PMCID: PMC4283695

  114. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging
    L. Ritsma, S. I. J. Ellenbroek, A. Zomer, H. J. Snippert, F. J. de Sauvage, B. D. Simons, H. Clevers and J. van Rheenen
    Nature 507, 362-365 (2014) | pdf | doi:10.1038/nature12972 | PMCID: PMC3964820
    Preview: Ballroom Dancing with Stem Cells: Placement and Displacement in the Intestinal Crypt

  115. flowerBiased competition between Lgr5 intestinal stem cells by oncogenic K-ras induces clonal expansion
    H. J. Snippert, A. G. Schepers, J. H. van Es, B. D. Simons and H. Clevers
    EMBO Reports 55, 62-69 (2014) | pdf | doi:10.1002/embr.201337799 | PMCID: PMC3983678

  116. Distinct fibroblast lineages determine dermal architecture in skin development and repair
    R. R. Driskell, B. M. Lichtenberger, E. Hoste,K. Kretzschmar, B. D. Simons, M. Charalambous, S. R. Ferron, Y. Herault, G. Pavlovic, A. C. Ferguson-Smith and F. M. Watt
    Nature 504, 277-281 (2013) | pdf | doi:10.1038/nature12783 | PMCID: PMC3868929
    F1000 Recommendation

  117. Stem cell renewal theory turns 60
    B. D. Simons
    Nature Reviews: Molecular Cell Biology (journal club), 14, 754 (2013) | pdf | doi:10.1038/nrm3706

  118. Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors
    V. H. Teixeira, P. Nadarajan, T. A. Graham, C. P. Pipinikas, J. M. Brown, M. Falzon, E. Nye, R. Poulsom, D. Lawrence, N. A. Wright, S. McDonald, A. Giangreco, B. D. Simons* and S. M. Janes*
    eLife, 2013 Oct 22;2:e00966 | doi:10.7554/eLife.00966 | PMCID: PMC3804062
    Commentary: Stem cells: What silent mutations say about the human airways

  119. Getting your gut into shape
    B. D. Simons
    Science (Perspective) 342, 203-204 (2013) | pdf | doi:10.1126/science.1245288

  120. Unravelling stem cell dynamics by lineage tracing
    C. Blanpain and B. D. Simons
    Nature Reviews Molecular Cell Biology 14, 489-502 (2013) | pdf | doi:10.1038/nrm3625

  121. Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion
    D. G. Kent, J. Li, H. Tanna, J. Fink, K. Kirschner, D. C. Pask, Y. Silber, T. L. Hamilton, R. Sneade, B. D. Simons and A. R. Green
    PLoS Biology 11, e1001576 (2013) | pdf | doi:10.1371/journal.pbio.1001576 | PMCID: PMC3672217

  122. Multipotent and unipotent progenitors contribute to prostate postnatal development
    M. Ousset, A. van Keymuelen, G. Bouvencourt, N. Sharma, Y. Achouri, B. D. Simons and C. Blanpain
    Nature Cell Biology 14, 1131-8 (2012) | pdf | doi:10.1038/ncb2600
    F1000 recommendation

  123. How variable clones build and invariant retina
    J. He, G. Zhang, A. D. Almeida, M. Cayouette, B. D. Simons, and W. A. Harris
    Neuron 75, 786-798 (2012) | pdf | doi:10.1016/j.neuron.2012.06.033 | PMCID: PMC3485567
    Preview: Deterministic or Stochastic Choices in Retinal Neuron Specification

  124. Distinct contribution of stem cells and progenitors to epidermal homeostasis and repair
    G. Mascre, B. Drogat, S. Dekoninck, K. K. Youseff, S. Brohee, P. Sotiropoulou, B. D. Simons* and C. Blanpain*
    Nature, 489, 257-62 (2012) | pdf | doi:10.1038/nature11393 |
    Research Highlight: Hierarchy in the population
    News and Views: Dormant and restless skin stem cells
    F1000 recommendation

  125. A single progenitor population switches behavior to maintain repair esophageal epithelium
    D. P. Doupe, M. P. Alcolea, A. Roshan, G. Zhang, A. M. Klein, B. D. Simons and P. H. Jones
    Science 337, 1091-1093 (2012) | pdf | doi:10.1126/science.1218835 | PMCID: PMC3527005
    Commentary: Esophageal Stem Cells, Where Art Thou?

  126. Defining the mode of tumour growth by clonal analysis
    G. Driessens, B. Beck, A. Caauwe, B. D. Simons* and C. Blanpain*
    Nature 488, 527-530 (2012) | pdf | doi:10.1038/nature11344 | PMCID: PMC5553110
    Commentaries: Nature news | Nature, News and Views | Science Now | Cancer research UK |
    Press reports: BBC News | Boston Globe | Dail Mail | eCancer | Independent | LA Times | NPR News |
    F1000 Recommendation

  127. Drosophila midgut homeostasis involves neutral competition between symmetrically dividing stem cells
    J. de Navascues, C. Perdigoto, A. Bardin, A. Martinez-Arias and B. D. Simons
    EMBO Journal 31, 2473-85 (2012) | pdf | doi:10.1038/emboj.2012.106 | PMCID: PMC3365418
    Commentary: Intestinal stem cells: no longer immortal but ever so clever...
    F1000 Recommendation

  128. Patterning as a signature of human epidermal stem cell regulation
    A. M. Klein, D. P. Doupe, B. Nikolaidou-Neokosmidou, P. H. Jones and B. D. Simons
    J. R. Soc. Interface 8, 1815-1824 (2011) | pdf | doi:10.1098/rsif.2011.0240 | PMCID: PMC3203489

  129. Stem cell self-renewal in intestinal crypt
    B. D. Simons and H. Clevers
    Experimental Cell Research 317, 2719-2724 (2011) | pdf | doi:10.1016/j.yexcr.2011.07.010

  130. Universal patterns of stem cell fate in cycling tissues
    A. M. Klein and B. D. Simons
    Development 138, 3103-3111 (2011) | pdf | doi:10.1242/dev.060103
    F1000 recommendation

  131. Strategies of stem cell self-renewal in adult tissues
    B. D. Simons and H. Clevers
    Cell 145, 851-862 (2011) | pdf | doi:10.1016/j.cell.2011.05.033

  132. Reconstruction of rat retinal progenitor cell lineages reveals a surprising degree of stochasticity in cell fate decisions
    F. L. A. F. Gomes, G. Zhang, F. Carbonell, J. A. Correa, W. A. Harris, B. D. Simons, and M. Cayouette
    Development 138, 227-235 (2011) | pdf | doi:10.1242/dev.059683 | PMCID: PMC3005599
    F1000 recommendation

  133. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
    H. J. Snippert, L. G. van der Flier, T. Sato, J. H. van Es, M. van den Born, C. Kroon-Veenboer, N. Barker, A. M. Klein, J. van Rheenen, B. D. Simons and H. Clevers
    Cell 143, 134-144 (2010) | pdf | doi:10.1016/j.cell.2010.09.016
    Commentaries: Nature Reviews: Molecular Cell Biology | Developmental Cell | Nature News and Views
    F1000 Recommendation

  134. Intestinal stem cell replacement follows a pattern of neutral drift
    C. Lopez-Garcia, A. M. Klein, B. D. Simons* and D. J. Winton*
    Science 330, 822-825 (2010) | pdf | doi:10.1126/science.1196236
    Commentary: What's all the noise about developmental stochasticity?

  135. Mouse germ line stem cells undergo rapid and stochastic turnover
    A. M. Klein, T. Nakagawa, R. Ichikawa, S. Yoshida and B. D. Simons
    Cell Stem Cell 7, 214-224 (2010) | pdf | doi:10.1016/j.stem.2010.05.017

  136. Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia
    A. M. Klein, D. E. Brash, P. H. Jones and B. D. Simons
    Proceedings of the National Academy of Sciences (USA) 107, 270-5 (2010) | pdf | doi:10.1073/pnas.0909738107 | PMCID: PMC2806764

  137. The ordered architecture of ear epidermis is maintained by progenitor cells with random fate
    D. P. Doupe, A. M. Klein, B. D. Simons and P. H. Jones
    Developmental Cell 18, 317 (2010) | pdf | doi:10.1016/j.devcel.2009.12.016

  138. Epidermal homeostasis: do committed progenitors work while stem cells sleep?
    P. H. Jones and B. D. Simons
    Nature Reviews: Molecular Cell Biology 9 , 82-8 (2008) | pdf | doi:10.1038/nrm2292

  139. Mechanism of murine epidermal maintenance: Cell division and the Voter Model
    A. M. Klein, D. P. Doupe, P. H. Jones and B. D. Simons
    Phys. Rev. E. 77, 031907 (2008) | pdf | doi:10.1103/PhysRevE.77.031907

  140. Sic transit gloria: Farewell to the epidermal transit amplifying cell?
    P. H. Jones, B. D. Simons and F. M. Watt
    Cell Stem Cell 1, 371 (2007) | pdf | doi:10.1016/j.stem.2007.09.014

  141. Kinetics of cell division in epidermal maintenance
    A. M. Klein, D. P. Doupe, P. H. Jones and B. D. Simons
    Phys. Rev. E. 76, 021910 (2007) | pdf | doi:10.1103/PhysRevE.76.021910

  142. A single type of progenitor cell maintains the epidermis
    E. Clayton, D. P. Doupe, A. M. Klein, D. Winton, B. D. Simons and P. H. Jones
    Nature 446, 185 (2007) | pdf | doi:10.1038/nature05574
    F1000 Recommendation

  143. Vesicles and onion phases in dilute surfactant solutions
    B. D. Simons and M. E. Cates
    J. de Physique II (Paris) 2, 1439-1451 (1992) | pdf | doi:10.1051/jp2:1992211

  144. Stability of dipolar fluid membranes
    B. D. Simons
    J. de Physique II (Paris) 2, 1141-1148 (1992) | pdf | doi:10.1051/jp2:1992192